CSR-1 GFP in C. elegans
Science: Projects and Publications
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CSR-1 Isoforms
The two isoforms of the essential Argonaute CSR-1 only differ by the inclusion of 164 amino acids at the N-terminus. But the two proteins also have highly different expression patterns and roles in development!
Ustilago maydis
Huitlacoche is the name of the mushrooms produced by the fungus Ustilago maydis, and is a delicacy in much of Mexico. I spent 3 years in undergrad studying how different combinations of corn and U. maydis can be used to make the best huitlacoche.
Publications
P Granules Protect RNA Interference Genes from Silencing by piRNAs
John Paul T Ouyang, Andrew Folkmann, Lauren Bernard, Chih-Yung Lee, Uri Seroussi, Amanda G Charlesworth, Julie M Claycomb, Geraldine Seydoux
Developmental cell 2019 Sep 23;50(6):716-728.e6.
doi: 10.1016/j.devcel.2019.07.026.
Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility
Amanda G Charlesworth, Uri Seroussi, Nicolas J Lehrbach, Mathias S Renaud, Adam E Sundby, Ruxandra I Molnar, Robert X Lao, Alexandra R Willis, Jenna R Woock, Matthew J Aber, Annette J Diao, Aaron W Reinke, Gary Ruvkun, Julie M Claycomb
Nucleic acids research 2021 Sep 7;49(15):8836-8865.
doi: 10.1093/nar/gkab619.
Next-Gen Learning: The C. elegans Approach
Amanda G Charlesworth, Uri Seroussi, Julie M Claycomb
Cell 2019 Jun 13;177(7):1674-1676.
doi: 10.1016/j.cell.2019.05.039.
A journey to ‘tame a small metazoan organism’, ‡ seen through the artistic eyes of C. elegans researchers
Eleni Gourgou, Alexandra R Willis, Sebastian Giunti, Maria J De Rosa, Amanda G Charlesworth, Mirella Hernandez Lima, Elizabeth Glater, Sonja Soo, Bianca Pereira, Kübra Akbaş, Anushka Deb, Madhushree Kamak, Mark W Moyle, Annika Traa, Aakanksha Singhvi, Surojit Sural, Eugene Jennifer Jin
Journal of Neurogenetics Sep-Dec 2020;34(3-4):549-560.
doi: 10.1080/01677063.2020.1839449.
Awards
Ontario Graduate Scholarship
2016, 2017 & 2021
U of T
Provincial Award
Presentation Award
July 2020
Toronto RNA Enthusiasts’ Day
Meeting Award
Poster Prize- 3rd place
Sept 2016
RiboClub annual meeting
Meeting Award
Worm Art Show
2018 and 2021
Digital Media category winner
Meeting award
Best Student Presentation
June 2019
Collaborative Dev bio retreat
Meeting Award
Best Oral Presentation award
Aug 2019
Ontario Cell Biology Symposium
Meeting Award